Hormonal polypeptides and amine metabolites in small cell carcinoma of the lung, with special reference to stage and subtypes
Open Access
- 15 March 1980
- Vol. 45 (6), 1432-1437
- https://doi.org/10.1002/1097-0142(19800315)45:6<1432::aid-cncr2820450622>3.0.co;2-z
Abstract
To elucidate the ectopic hormonal pattern in patients with small cell carcinoma of the lung, plasma ACTH, serum calcitonin, serum gastrin, plasma glucagon, serum insulin, plasma secretin, plasma VIP, serum growth hormone, serum hCG/LH, the total of serum hCG and hCG‐β‐subunit, serum α‐subunit, serum human placental lactogen, urine ADH, urine 5‐HIAA, urine VMA, urine HVA, and urine hCG‐LH were measured prior to therapy in 75 patients. Twenty‐two patients (29%) had elevated plasma ACTH, and 18 of these had concomitant increased values of corticosteroids in a 24‐hour urine sample. Forty‐eight patients (64%) were found to have elevated serum calcitonin, and one‐third of the patients were diagnosed as having the ectopic ADH syndrome. Serum gastrin concentrations were increased in 20% of the patients, but the elevations were marginal in almost all cases. None of the remaining substances was found to be significantly elevated. Concentrations of plasma ACTH, serum calcitonin, and urine ADH were not found to be correlated with the stage of the disease, and no correlation of these substances with the histological subtypes of small cell carcinoma was disclosed.This publication has 25 references indexed in Scilit:
- Variable Content of Histaminase, L-Dopa Decarboxylase and Calcitonin in Small-Cell Carcinoma of the LungNew England Journal of Medicine, 1978
- Peritoneoscopy in the staging of 190 patients with small-cell anaplastic carcinoma of the lung with special reference to subtypingCancer, 1978
- A COMPARATIVE STUDY ON BIOASSAY AND RADIOIMMUNOASSAY OF VASOPRESSIN IN HUMAN URINEActa Endocrinologica, 1978
- Small Cell Carcinoma of the Lung: Serum Calcitonin and Serum Histaminase (Diamine Oxidase) at Basal Levels and Stimulated by PentagastrinActa Medica Scandinavica, 1978
- Endocrine-like cells of the pulmonary epithelium of the human adult lungCell and tissue research, 1977
- LUNG TUMOURS AND ACTH PRODUCTIONClinical Endocrinology, 1977
- Ectopic ACTH Production in Carcinoma of the LungJCI Insight, 1974
- SERUM CALCITONIN IN MEDULLARY THYROID CARCINOMAActa Medica Scandinavica, 1974
- RADIOIMMUNOASSAY OF URINARY HUMAN CHORIONIC GONADOTROPHINActa Endocrinologica, 1971
- Oat-cell carcinoma of the lung. Its origin and relationship to bronchial carcinoidCancer, 1968