Curcumin (Diferuloylmethane) Down-Regulates Expression of Cell Proliferation and Antiapoptotic and Metastatic Gene Products through Suppression of IκBα Kinase and Akt Activation
Top Cited Papers
- 11 October 2005
- journal article
- Published by American Society for Pharmacology & Experimental Therapeutics (ASPET) in Molecular Pharmacology
- Vol. 69 (1), 195-206
- https://doi.org/10.1124/mol.105.017400
Abstract
Curcumin (diferuloylmethane), an anti-inflammatory agent used in traditional medicine, has been shown to suppress cellular transformation, proliferation, invasion, angiogenesis, and metastasis through a mechanism not fully understood. Because several genes that mediate these processes are regulated by nuclear factor-κB (NF-κB), we have postulated that curcumin mediates its activity by modulating NF-κB activation. Indeed, our laboratory has shown previously that curcumin can suppress NF-κB activation induced by a variety of agents (Keywords
This publication has 54 references indexed in Scilit:
- The role of c-myc in regulation of translation initiationOncogene, 2004
- Evidence That Glutathione Depletion Is a Mechanism Responsible for the Anti-Inflammatory Effects of Ethyl Pyruvate in Cultured Lipopolysaccharide-Stimulated RAW 264.7 CellsJournal of Pharmacology and Experimental Therapeutics, 2003
- IL‐1β mediated up‐regulation of HIF‐lα via an NFkB/COX‐2 pathway identifies HIF‐1 as a critical link between inflammation and oncogenesisThe FASEB Journal, 2003
- Inhibition of NF-κB Sensitizes A431 Cells to Epidermal Growth Factor-induced Apoptosis, whereas Its Activation by Ectopic Expression of RelA Confers ResistancePublished by Elsevier ,2003
- Natural Products as Sources of New Drugs over the Period 1981−2002Journal of Natural Products, 2003
- Post-activation Turn-off of NF-κB-dependent Transcription Is Regulated by Acetylation of p65Journal of Biological Chemistry, 2003
- Nuclear transcription factor-κB as a target for cancer drug developmentLeukemia, 2002
- Transcriptional regulation of bcl-2 by nuclear factor κB and its significance in prostate cancerOncogene, 2001
- The prosurvival Bcl-2 homolog Bfl-1/A1 is a direct transcriptional target of NF-kappa B that blocks TNFalpha -induced apoptosisGenes & Development, 1999
- Phosphorylation of NF-κB p65 by PKA Stimulates Transcriptional Activity by Promoting a Novel Bivalent Interaction with the Coactivator CBP/p300Molecular Cell, 1998