Age dependence of human plasma renin substrate
- 1 January 1981
- journal article
- research article
- Published by Taylor & Francis in Scandinavian Journal of Clinical and Laboratory Investigation
- Vol. 41 (2), 167-170
- https://doi.org/10.3109/00365518109092029
Abstract
Renin substrate (angiotensinogen) was measured with an assay employing exhaustive incubation of plasma with purified human kidney renin and radioimmunoassay of the angiotensin I (AI) generated. Plasma renin substrate concentration was higher at the age of 3 days (females: 2028 ± 551, males: 1951 ± 565 μg AI/1, mean±SD) than in age group 0–15 years (females: 1513± 555, males: 1263±392μg AI/1). Plasma renin substrate concentration at the age over 15 years (females: 1780±464, males 1752±321 μg AI/1) was higher than in children 0–15 years. Expectedly, high concentrations of plasma renin substrate were found in pregnant women at term (4127 ± 1961 μg AI/1).Keywords
This publication has 8 references indexed in Scilit:
- Renin and renin substrate in primary adrenal insufficiencyAmerican Journal Of Medicine, 1979
- Measurement of Plasma Renin Substrate by Radioimmunoassay of Angiotensin I: Concentration in Syndromes Associated with Steroid ExcessJournal of Clinical Endocrinology & Metabolism, 1973
- A procedure for the determination of a renin inhibitor in human plasmaClinica Chimica Acta; International Journal of Clinical Chemistry, 1973
- Renin in anephric man: Case report with physiologic studiesAmerican Journal Of Medicine, 1972
- Plasma Renin Activity and Renin-Substrate Concentration in Patients with Liver DiseaseCirculation Research, 1967
- Extraction, Purification, and Assay of Human Renin Free of AngiotensinaseCirculation Research, 1966