OBSERVATIONS ON THE DIFFERING NATURE OF THE DNA OF LYMPHOCYTES AND NEUTROPHILE LEUCOCYTES
- 1 June 1962
- journal article
- research article
- Published by Proceedings of the National Academy of Sciences in Proceedings of the National Academy of Sciences
- Vol. 48 (6), 978-982
- https://doi.org/10.1073/pnas.48.6.978
Abstract
An immuno-cyto-chemical study using anti-DNA antibodies revealed a profound antigenic difference between the DNA of neutro-phils and that of lymphocytes. The former is split by DNase I and n, the latter by DNase I. The basis of this difference has not been determined. Several possible explanations are considered, including that of a 3[image]-3[image], 5[image]-5[image] reciprocal linkage for the lymphocyte DNA rather than the conventional 3[image]-5[image] linkage of the neutrophil DNA. Leukemic leucocytes and the blastic cells of normal bone marrow did not react with anti-DNA antibodies of neutrophils and lymphocytes.Keywords
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