INFLUENCE OF EXPERIMENTAL KIDNEY DAMAGE ON HISTOCHEMICALLY DEMONSTRABLE LIPASE ACTIVITY IN THE RAT. COMPARISON WITH ALKALINE PHOSPHATASE ACTIVITY.
Open Access
- 30 June 1946
- journal article
- Vol. 84 (1), 25-36
Abstract
Lipase activity was found in the cytoplasm of the proximal convoluted tubules in tissue sections of rat, rabbit, dog, mouse, hamster, and guinea pig, stained according to Gomori's method. Uranium and mercury poisoning do not inactivate the enzyme in necrotic cells of the proximal convoluted tubules. Its activity diminished in the atrophic and regenerating cells of the kidneys of rats, surviving the acute phase of the intoxication. In the acute stage of choline deficiency marked reduction in enzymatic activity was seen in the necrotic tubules, and in the atrophied and regenerating tubules in the subacute stage. Lipase activity was markedly diminished in hydronephrotic kidneys 10 to 12 days after ligation of the ureter. In sections stained for alkaline phosphatase activity nearly identical alterations were found. Experimental damage influences both histochemically demonstrable enzymes in a similar manner.This publication has 10 references indexed in Scilit:
- THE DISAPPEARANCE OF PHOSPHATASE FROM THE HYDRONEPHROTIC KIDNEYThe Journal of Experimental Medicine, 1943
- THE INTERRELATIONS OF SERUM LIPIDS IN PATIENTS WITH DISEASES OF THE KIDNEYS 1JCI Insight, 1943
- CHANGES IN LIPID CONTENT OF SERUM AND OF LIVER FOLLOWING BILATERAL RENAL ABLATION OR URETERAL LIGATIONThe Journal of Experimental Medicine, 1943
- Calcification and phosphatase1943
- The renal tubule (Nephron) as affected by mercury1942
- Renal Hyperlipemia in DogsScience, 1942
- A histochemical study of the distribution of alkaline phosphatase in various normal and neoplastic tissues1941
- STRUCTURAL AND FUNCTIONAL TRANSFORMATIONS IN THE TUBULAR EPITHELIUM OF THE DOG'S KIDNEY IN CHRONIC BRIGHT'S DISEASE AND THEIR RELATION TO MECHANISMS OF RENAL COMPENSATION AND FAILUREThe Journal of Experimental Medicine, 1941
- Distribution of Enzymes in Tissue and Cells: Harvey Lecture, March 16, 1939.1939
- THE HISTOGENESIS OF CHRONIC URANIUM NEPHRITIS WITH ESPECIAL REFERENCE TO EPITHELIAL REGENERATIONThe Journal of Experimental Medicine, 1915