Epstein–Barr virus-induced cell fusion
- 1 September 1980
- journal article
- Published by Springer Nature in Nature
- Vol. 287 (5778), 164-165
- https://doi.org/10.1038/287164a0
Abstract
Serological and molecular biological studies have shown an association between Epstein--Barr virus (EBV) and nasopharyngeal carcinoma. Although it has been shown that the epithelioid tumour cells carry EBV genomes, they are apparently devoid of receptors for EBV (H.W., unpublished observations). Other have suggested that fusion of EBV carrying cells with epithelial cells may be the mode of entry of the virus into cells unable to absorb the virus and that this may be mediated by one of the known syncytium-forming viruses which inhabit the respiratory tract (for example, members of the paramyxovirus group). de Thé and colleagues suggested that intercellular bridges could be seen in NPC tumour material. We have developed a technique which permits the preparation of stable monolayers of viable human lymphoblastoid cell lines. Using this technique we have now demonstrated that EBV can induce fusion between EBV-superinfected lymphoblastoid cells and cells devoid of EBV receptors.Keywords
This publication has 9 references indexed in Scilit:
- Mechanisms of infection with Epstein-Barr virus III. The synthesis of proteins in superinfected Raji cellsVirology, 1978
- Cytogenetics of malignant epithelial cells and lymphoblastoid cell lines from nasopharyngeal carcinomaBritish Journal of Cancer, 1978
- Attempts to detect virus-specific DNA sequences in human tumorsMedical Microbiology and Immunology, 1975
- EBV DNA in Nonlymphoid Cells of Nasopharyngeal Carcinomas and in a Malignant Lymphoma Obtained after Inoculation of EBV into Cottontop MarmosetsCold Spring Harbor Symposia on Quantitative Biology, 1974
- EB Viral Genomes in Epithelial Nasopharyngeal Carcinoma CellsNature New Biology, 1973
- Identification of a Critical Period during the S Phase for Activation of the Epstein-Barr Virus by 5-IododeoxyuridineNature New Biology, 1973
- Detection of Epstein-Barr Viral Genome in Nonproductive CellsNature New Biology, 1971
- Differential Reactivity of Human Serums with Early Antigens Induced by Epstein-Barr VirusScience, 1970
- PRECIPITATING ANTIBODY IN HUMAN SERUM TO AN ANTIGEN PRESENT IN CULTURED BURKITT'S LYMPHOMA CELLSProceedings of the National Academy of Sciences, 1966