Clinical Isolates of Enterobacteriaceae Producing Extended-Spectrum β-Lactamases: Prevalence of CTX-M-3 at a Hospital in China
Open Access
- 1 February 2003
- journal article
- Published by American Society for Microbiology in Antimicrobial Agents and Chemotherapy
- Vol. 47 (2), 790-793
- https://doi.org/10.1128/aac.47.2.790-793.2003
Abstract
The prevalence of extended-spectrum β-lactamase-producing strains was demonstrated in 5 of 44 (11.4%) Escherichia coli , 17 of 43 (39.5%) Klebsiella pneumoniae , 3 of 50 (6.0%) Enterobacter cloacae , and 2 of 25 (8.0%) Citrobacter freundii strains at a teaching hospital in China. Nineteen of these 27 strains expressed CTX-M-3 β-lactamase (pI 8.6). A subset of the clinical isolates expressing the CTX-M-3 enzyme, tested by pulsed-field gel electrophoresis, revealed multiple clones. Five isolates expressed a novel enzyme, SHV-43 (pI 8.0), which had two substitutions (Leu113Phe and Thr149Ser) compared with SHV-1.Keywords
This publication has 25 references indexed in Scilit:
- bla CTX-M-2 Is Located in an Unusual Class 1 Integron (In35) Which Includes Orf513Antimicrobial Agents and Chemotherapy, 2002
- Development of a Sensitive and Specific Enzyme-Linked Immunosorbent Assay for Detecting and Quantifying CMY-2 and SHV β-LactamasesJournal of Clinical Microbiology, 2002
- Plasmid-Determined AmpC-Type β-LactamasesAntimicrobial Agents and Chemotherapy, 2002
- Countrywide Spread of CTX-M-3 Extended-Spectrum β-Lactamase-Producing Microorganisms of the Family Enterobacteriaceae in PolandAntimicrobial Agents and Chemotherapy, 2002
- Editorial Response: Extended-Spectrum -Lactamases: A Call for Improved Detection and ControlClinical Infectious Diseases, 1999
- Phenotypic and genotypic characterizations of chinese strains of Escherichia coli producing extended-spectrum β-lactamasesDiagnostic Microbiology and Infectious Disease, 1999
- Editorial Response: Epidemiology of Extended‐Spectrum β‐LactamasesClinical Infectious Diseases, 1998
- Cloning and nucleotide sequencing of the gene encoding the β-lactamase from Citrobacter diversusFEMS Microbiology Letters, 1991
- Novel plasmid-mediated beta-lactamase (TEM-10) conferring selective resistance to ceftazidime and aztreonam in clinical isolates of Klebsiella pneumoniaeAntimicrobial Agents and Chemotherapy, 1989
- The Use of Analytical Isoelectric Focusing for Detection and Identification of -LactamasesJournal of General Microbiology, 1975