Structure and Biodistribution Relationships of Photodynamic Sensitizers*
- 1 September 1996
- journal article
- review article
- Published by Wiley in Photochemistry and Photobiology
- Vol. 64 (3), 469-485
- https://doi.org/10.1111/j.1751-1097.1996.tb03093.x
Abstract
Photodynamic therapy (PDT) has, during the last quarter century, developed into a fully fledged biomedical field with its own association, the International Photodynamic Association (IPA) and regular conferences devoted solely to this topic. Recent approval of the first PDT sensitizer, Photofrin (porfimer sodium), by health boards in Canada, Japan, the Netherlands and United States for use against certain types of solid tumors represents, perhaps, the single most significant-indicator of the progress of PDT from a laboratory research concept to clinical reality. The approval of Photofrin will undoubtedly encourage the accelerated development of second-generation photosensitizers, which have recently been the subject of intense study. Many of these second-generation drugs show significant differences, when compared to Photofrin, in terms of treatment times postinjection, light doses and drug doses required for optimal results. These differences can ultimately be attributed to variations in either the quantum efficiency of the photosensitizer in situ, which is in turn affected by aggregation state, localized concentration of endogenous quenchers and primary photophysics of the dye, or the intratumoral and intracellular localization of the photosensitizer at the time of activation with light. The purpose of this review is to bring together data relating to the biodistribution and pharmacokinetics of second-generation sensitizers and attempt to correlate this with structural and electronic features of these molecules. As this requires a clear knowledge of photosensitizer structure, only chemically well-characterized compounds are included, e.g. Photofrin and crude sulfonated phthalocyanines have been excluded as they are known to be complex mixtures. Nonporphyrin-based photosensitizers, e.g. rose bengal and the hypericins, have also been omitted to allow meaningful comparisons to be made between different compounds. As the intracellular distribution of photosensitizers to organelles and other subcellular structures can have a large effect on PDT efficacy, a section will be devoted to this topic.Keywords
This publication has 68 references indexed in Scilit:
- Pharmacokinetic and tumour-photosensitizing properties of the cationic porphyrin meso-tetra(4N-methylpyridyl)porphineCancer Letters, 1993
- Effect of drug-light interval on photodynamic therapy with meta-tetrahydroxyphenylchlorin in malignant mesotheliomaInternational Journal of Cancer, 1993
- Tissue Distribution of BacteriochlorinaLabelled with99mTc-pertechnetate in Hamster Greene MelanomaInternational Journal of Radiation Biology, 1993
- Subcellular localization, redistribution and photobleaching of sulfonated aluminum phthalocyanines in a human melanoma cell lineInternational Journal of Cancer, 1991
- Sensitizer for photodynamic therapy of cancer: A comparison of the tissue distribution of photofrin ii and aluminum phthalocyanine tetrasulfonate in nude mice bearing a human malignant tumorInternational Journal of Cancer, 1991
- Liposome- or LDL-administered Zn(II)-phthalocyanine as a photodynamic agent for tumours III. Effect of cholesterol on pharmacokinetic and phototherapeutic propertiesLasers in Medical Science, 1990
- Author indexJournal of Photochemistry and Photobiology A: Chemistry, 1990
- Biodistribution of tritiated benzoporphyrin derivative (3H-BPD-MA), a new potent photosensitizer, in normal and tumor-bearing miceJournal of Photochemistry and Photobiology B: Biology, 1990
- Biodistribution of55Fe (II) phthalocyanine tetrasulphonate (55Fe (II)-TsPc)Lasers in Medical Science, 1990
- New method of photosensitizer accumulation for photodynamic therapy in an experimental liver tumorLasers in Surgery and Medicine, 1989