Über die Hemmung der neuromuskulären Übertragung durch einige Antibiotika

Abstract

Neomycin, polymyxin B, streptomycin, dihydrostreptomycin and kanamycin inhibit neuromuscular transmission. The membrane stabilizing action of the antibiotics could be demonstrated by means of the acetylcholine contraction of the denervated rat diaphragm. The neuromuscular blocking effect of antibiotics alone and in combination with d-tubocurarine, was measured with phrenic nerve-diaphragm preparations from the rat. Additive inhibition by d-tubocurarine and the antibiotics was also demonstrated in the intact rabbit by measuring the head-drop dose. The consequences of these findings for the prevention and treatment of neuromuscular block due to antibiotics are discussed.