Activation of Membrane-Bound Adenylate Cyclase by Glucagon in Neurospora crassa
- 1 October 1972
- journal article
- Published by Proceedings of the National Academy of Sciences in Proceedings of the National Academy of Sciences
- Vol. 69 (10), 2870-2873
- https://doi.org/10.1073/pnas.69.10.2870
Abstract
Membrane-bound adenylate cyclase in Neurospora crassa is activated by glucagon. Half-maximal effect is observed at hormone concentrations of about 10 nM. After solubilization of the enzyme with Lubrol-PX, the glucagon effect is lost. Incubation of neurospora cells with glucagon leads to a decrease in the activity of glycogen synthetase (EC 2.4.1.11) and to an increase in the activity of glycogen phosphorylase (EC 2.4.1.1) and in the rate of glycogenolysis.Keywords
This publication has 15 references indexed in Scilit:
- Hormone action at the membrane level. II. The binding of epinephrine and glucagon to the rat liver plasma membraneBiochimica et Biophysica Acta (BBA) - Biomembranes, 1970
- Interconvertible Forms of Glycogen Phosphorylase in Neurospora crassaProceedings of the National Academy of Sciences, 1970
- Solubilization of myocardial adenyl cyclaseBiochemical and Biophysical Research Communications, 1970
- Interconvertible forms of glycogen synthetase in Neurospora crassaBiochimica et Biophysica Acta (BBA) - Enzymology, 1969
- Adenyl cyclase in fat cells. II. Hormone receptors.1969
- Adenyl cyclase in plasma membrane preparations of sea urchin eggs and its increase in activity after fertilizationBiochemical and Biophysical Research Communications, 1968
- A simple, sensitive method for the assay of adenyl cyclase.1968
- METABOLISM OF ISOLATED FAT CELLS .V. PREPARATION OF GHOSTS AND THEIR PROPERTIES - ADENYL CYCLASE AND OTHER ENZYMES1967
- The preparation of 32P-labelled nucleoside 5′-monophosphatesBiochimica et Biophysica Acta (BBA) - Nucleic Acids and Protein Synthesis, 1966
- The role of cyclic-3',5'-AMP in responses to catecholamines and other hormones.1966