MISMATCHED HL-A HAPLOTYPES WITH ANTIGENS HL-A1, 3, AND 11 ASSOCIATED WITH EXCELLENT RENAL ALLOGRAFT FUNCTION

Abstract

SUMMARY In a no-exclusion study of 76 genotyped recipients of living related allografts, 51 received definitely mismatched haplotypes. Those mismatched haplotypes carrying the cross reacting antigens HL-A1,3, or 11 were associated with a significantly increased incidence of excellent functioning allografts—19—and only a single failure (P < 0.001). In those patients with a mismatched haplotype without HL-A1,3, or 11, allograft failures—13—exceeded excellent functioning allografts—11. Also evaluated were the possible roles of other donor cross reacting groups, donor-recipient cross reacting antigens, specific recipient antigens such as HL-A1, lymphocytotoxic, antinuclear, and anti-glomerular basement membrane antibodies (anti-GBM), the inflammatory response and delayed hypersensitivity (DH) to dinitrochlorobenzene (DNCB), preexisting DH, and the response of recipient lymphocytes to phytohemagglutinin.