SPLENECTOMY IN RHEUMATOID ARTHRITIS
- 31 March 1953
- journal article
- research article
- Published by American College of Physicians in Annals of Internal Medicine
- Vol. 38 (4), 787-813
- https://doi.org/10.7326/0003-4819-38-4-787
Abstract
Exptl. evidence is presented that splenectomy results in hypertrophy of the anterior lobe of the pituitary gland in animals and possibly in human beings. Splenectomy in patients suffering from rheumatoid arthritis resulted in improvement of the arthritis and of the blood picture. Both an anti-rheumatic and hemato-poietic response results from such operative procedure. The result is similar to that obtained by admn. of either cortisone or corticotropin, but the effects are much more lasting. The antirheumatic response is characterized by decrease in joint pain and swelling and increase in mobility. Hematopoietic response is indicated by a rise in the erythrocytes, hemoglobin and platelets, and a normalization of the various leukocytic components.Keywords
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