EFFECTS OF ORGANOPHOSPHOROUS COMPOUNDS, OXIMES AND ATROPINE INJECTED INTO THE THIRD VENTRICLE OF UNANAESTHETIZED DOGS
Open Access
- 1 February 1962
- journal article
- research article
- Published by Wiley in British Journal of Pharmacology and Chemotherapy
- Vol. 18 (1), 19-28
- https://doi.org/10.1111/j.1476-5381.1962.tb01146.x
Abstract
The effects of four organophosphorous compounds, three oximes and atropine sulphate, injected through an indwelling cannula into the third ventricle of unanaesthetized dogs were examined. The effects of 200 μg of dyflos were involuntary micturition, defaecation, akinesia of hind limbs and pronounced disturbances of awareness; those of 100 μg of ethyl pyrophosphate were tremor, restlessness and signs of fear; 500 μg to 5 mg of dyflos and 250 μg to 500 μg of ethyl pyrophosphate caused vomiting, salivation, twitches of facial muscles and recurrent epileptiform seizures. The injection of 40 to 80 mg of dimefox and of 50 mg of schradan elicited involuntary micturition, vomiting, salivation and defaecation. These effects occur probably after these substances have passed into the blood stream and have beep converted in the liver to potent anticholinesterases. This view is supported by the finding of reduced blood cholinesterase activity. At a dose level of 12.5 mg, 1,1′-trimethylenebis(4-hydroxyiminomethylpyridinium bromide) produced strong convulsions. At this dose level pralidoxime iodide and diacetyl monoxime produced no observable effects. Atropine sulphate in a dose of 1 mg caused disturbances in consciousness and behaviour followed by convulsions. Intraventricular atropine and to a minor extent intraventricular oximes were able to antagonize the effects of intraventricular ethyl pyrophosphate. Pralidoxime iodide exerted a strong antagonistic effect also on intravenous injection.Keywords
This publication has 27 references indexed in Scilit:
- Parasympatholytic Effects of TMB-4 [1,1-Trimethylene-bis (4-formylpyridinium Bromide)-dioximel and some related Oximes in the Cat *).Acta Pharmacologica et Toxicologica, 2009
- In vivo reactivation by pam of brain cholinesterase inhibited by paraoxonBiochemical Pharmacology, 1960
- EFFECTS OF DIACETYL MONOXIME ON NEUROMUSCULAR TRANSMISSIONBritish Journal of Pharmacology and Chemotherapy, 1959
- PROTECTION AGAINST LETHAL ORGANOPHOSPHATE POISONING BY QUATERNARY PYRIDINE ALDOXIMESBritish Journal of Pharmacology and Chemotherapy, 1959
- Pyridine-2-Aldoxime Methiodide and Diacetyl Monoxime against Organophosphorus PoisoningScience, 1958
- THE PHYSIOLOGICAL BASIS OF CONSCIOUSNESS A CRITICAL REVIEWBrain, 1958
- EFFECTS IN MAN OF THE ANTICHOLINESTERASE COMPOUND SARIN (ISOPROPYL METHYL PHOSPHONOFLUORIDATE)1JCI Insight, 1958
- Pathways of absorption of protein from the cerebrospinal fluid: An autoradiographic study in the catThe Anatomical Record, 1957
- A Note on an Indwelling Cannula for Intraventricular Injection of Drugs in the Unanesthetized DogJournal of the American Pharmaceutical Association (Scientific ed.), 1956
- Experiments on the histologic locus of the hemato‐encephalic barrierJournal of Comparative Neurology, 1955