Highly stereoselective addition of Grignard reagents to C-cyclopropylnitrone via the bisected s-trans conformation. An efficient synthesis of PEDC, a potent NMDA receptor antagonist having a cyclopropane structure
- 8 July 2000
- journal article
- research article
- Published by Elsevier in Tetrahedron Letters
- Vol. 41 (28), 5373-5377
- https://doi.org/10.1016/s0040-4039(00)00823-6
Abstract
No abstract availableKeywords
This publication has 15 references indexed in Scilit:
- Open channel block of NMDA receptors by conformationally restricted analogs of milnacipran and their protective effect against NMDA-induced neurotoxicitySynapse, 1998
- Synthesis and Biological Activity of Conformationally Restricted Analogues of Milnacipran: (1S,2R)-1-Phenyl-2-[(R)-1-amino-2-propynyl]-N,N- diethylcyclopropanecarboxamide Is a Novel Class of NMDA Receptor Channel BlockerJournal of Medicinal Chemistry, 1998
- New aspects of catalytic asymmetric cyclopropanationTetrahedron, 1998
- Synthesis of (+)- and (−)-milnaciprans and their conformationally restricted analogsTetrahedron Letters, 1996
- Highly stereoselective nucleophilic addition to cyclopropyl carbonyls: The facial selectivity in the cyclopropyl ketones is opposite to that in the corresponding aldehydeTetrahedron Letters, 1996
- Conformational Restriction by Repulsion between Adjacent Substituents on a Cyclopropane Ring: Design and Enantioselective Synthesis of 1-Phenyl-2-(1-aminoalkyl)-N,N-diethylcyclopropanecarboxamides as Potent NMDA Receptor AntagonistsThe Journal of Organic Chemistry, 1996
- Synthesis and Biological Activity of Conformationally Restricted Analogs of Milnacipran: (1S,2R)-1-Phenyl-2-[(S)-1-aminopropyl]-N,N-diethylcyclopropanecarboxamide, an Efficient Noncompetitive N-Methyl-d-aspartic Acid Receptor AntagonistJournal of Medicinal Chemistry, 1996
- Cyclopropane amino acidsTetrahedron, 1990
- Use of cyclopropanes and their derivatives in organic synthesisChemical Reviews, 1989
- A novel asymmetric synthesis of substituted cyclopropanesJournal of the American Chemical Society, 1988