Slow release of anticancer drugs from porous calcium hydroxyapatite ceramic
- 1 May 1992
- journal article
- research article
- Published by Wiley in Journal of Orthopaedic Research
- Vol. 10 (3), 440-445
- https://doi.org/10.1002/jor.1100100317
Abstract
We have developed a new delivery system for sustained release of an anticancer drug (cis‐platinum) by enclosure into blocks of porous calcium hydroxyapatite ceramic. The slow release of this drug from this system was confirmed in in vitro experiments. When this system was implanted into normal back muscle, or the tibia, sustained release of cis‐platinum was observed during a 12‐week period after implantation. The diffusion rate of cis‐platinum into blood and other organs (liver, kidney, brain) was less than 10% of that at the implanted site. This delivery system placed into experimental tumors of mice also showed a uniform release of anticancer drug for more than 3 months. Inhibition of tumor growth was more marked after local implantation of this system than after intraperitoneal administration of cis‐platinum. These results indicate that this new approach to a drug delivery system may well have an important role in cancer chemotherapy. In bone tumors it is attractive because the mechanical strength of calcium hydroxyapatite ceramic permits partial surgical excision and replacement of the bone defect at the same time.Keywords
This publication has 12 references indexed in Scilit:
- Analysis of the biocompatibility of ALCAP ceramics in rat femursJournal of Biomedical Materials Research, 1988
- The Treatment of Metastatic Prostatic Cancer with the Slow Release LH-RH Analogue Zoladex ICI 118630British Journal of Urology, 1987
- Encapsulation of adriamycin in human erythrocytes.Proceedings of the National Academy of Sciences, 1986
- Extended immunosuppression with cyclophosphamide using controlled-release polymeric implantsInternational Journal of Immunopharmacology, 1985
- Bone ingrowth into three different porous ceramics implanted into the tibia of rats and rabbitsJournal of Orthopaedic Research, 1985
- The treatment of intravenously implanted Lewis lung carcinoma with two sustained release forms of 1-β-d-arabinofuranosylcytosineEuropean Journal of Cancer and Clinical Oncology, 1984
- Crystallized carbohydrate spheres as a slow release matrix for biologically active substancesBiomaterials, 1984
- Metastases from histologically benign giant-cell tumor of bone.The Journal of Bone & Joint Surgery, 1984
- Present and future applications of biomaterials in controlled drug delivery systemsBiomaterials, 1981
- Analysis for platinum in biological material by flameless atomic absorption spectrometry.Clinical Chemistry, 1977