Should Plasma or Urinary MHPG be Measured in Psychiatric Research? A Critical Comment
- 29 January 1986
- journal article
- Published by Royal College of Psychiatrists in The British Journal of Psychiatry
- Vol. 148 (1), 95-97
- https://doi.org/10.1192/bjp.148.1.95
Abstract
Many experimental findings suggest that disturbances of noradrenergic neurons in the CNS are involved in the pathogenesis of depressive disorders. Moreover, evidence indicates that adaptive changes of central noradrenergic neurons contribute to the biochemical mechanism of action of most anti-depressive treatments (Goodwin, 1984; Johnstone, 1982). Accordingly, assessing the activity of central noradrenergic neurons in depressive patients has become important in psychiatric research.Keywords
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