Influence of the mouse major histocompatibility complex, H-2, on liver adenylate cyclase activity and on glucagon binding to liver cell membranes

Abstract

The major histocompatibility complex of mice, the H-2 complex, regulates the steady-state level of cyclic(c)AMP in liver. This effect of H-2 may be due to an effect on hormone binding to receptors. In this study, liver membranes from animals of different H-2 types differed in their sensitivity to glucagon stimulation of adenylate cyclase and in the affinity of their receptors for glucagon. No H-2-associated differences were seen in basal, NaF-stimulated or GMP-PNP[5''-guanylyl imidophosphate]-stimulated adenylate cyclase.