STUDIES OF TUBERCLE BACILLUS-HISTIOCYTE RELATIONSHIPS
Open Access
- 1 September 1963
- journal article
- research article
- Published by Rockefeller University Press in The Journal of Experimental Medicine
- Vol. 118 (3), 371-386
- https://doi.org/10.1084/jem.118.3.371
Abstract
The mechanism of cellular resistance against virulent tubercle bacilli was analyzed. Immune rabbit histiocytes contained a substance capable of inducing cellular resistance in normal rabbits. Fractionation of these histiocytes indicated that the nuclear and mitochondrial fractions were inactive whereas the microsomal and ribosomal fractions were active. The ribonucleic acid nature of the active component in the ribosomes was indicated by the extraction of an active RNA from ribosomes and by inactivation of the ribosomal RNA with ribonuclease but not with deoxyribonuclease or trypsin.Keywords
This publication has 18 references indexed in Scilit:
- Appearance of Radioactivity in Mouse Cells after Administration of Labeled Macromolecular RNAScience, 1962
- EVIDENCE FOR THE PERSISTENCE IN PROTEIN SYNTHESIS OF AN INFORMATION TRANSFER MECHANISM AFTER THE REMOVAL OF GENESProceedings of the National Academy of Sciences, 1962
- IMMUNITY AGAINST TULAREMIA: PASSIVE PROTECTION OF MICE BY TRANSFER OF IMMUNE TISSUESThe Journal of Experimental Medicine, 1962
- STUDIES ON TUBERCLE BACILLUS-MONOCYTE RELATIONSHIPThe Journal of Experimental Medicine, 1961
- THE EFFECTS OF NUCLEIC ACIDS ON PITUITARY ACTH CONTENT1Endocrinology, 1961
- THE EFFECTS OF NUCLEIC ACIDS ON HOMOGRAFT TOLERANCE *Annals of the New York Academy of Sciences, 1960
- STUDIES ON TUBERCLE BACILLUS-MONOCYTE RELATIONSHIPThe Journal of Experimental Medicine, 1959
- STUDIES ON TUBERCLE BACILLUS-MONOCYTE RELATIONSHIPThe Journal of Experimental Medicine, 1956
- Infectivity of Ribonucleic Acid from Tobacco Mosaic VirusNature, 1956
- STUDIES ON THE IMMUNOLOGICAL RESPONSE TO FOREIGN TUMOR TRANSPLANTS IN THE MOUSEThe Journal of Experimental Medicine, 1955