Mutagenic effects of allylisothiocyanate inEscherichia coli WP 67
- 1 January 1982
- journal article
- research article
- Published by Springer Nature in Folia Microbiologica
- Vol. 27 (1), 25-31
- https://doi.org/10.1007/bf02883833
Abstract
A mutagenic effect of allylisothiocyanate (AITC) onE. coli WP 67 (trp uvrA polA) was only found in a test with metabolic activationin vitro. Mixed function oxidases containing cytochrome P-450 are not responsible for the conversion of AITC to mutagenic products. Liver microsomal fractions of rat, mouse, chinese hamster, goat and monkey were used forin vitro metabolic activation. The mutagenic effect of AITC differed in individual animal species according to the protein content in the microsomel fraction. Allylamine (formed by hydrolysis of AITC) did not exhibit any mutagenic effect.Keywords
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