EXPERIMENTAL INFECTION OF THE UPPER GENITAL TRACT OF FEMALE GRIVET MONKEYS WITH MYCOPLASMA FERMENTANS

Abstract

M. fermentans inoculated directly into the uterine tubes of female grivet monkeys produced a self-limiting acute salpingitis and parametritis. Inflammation was accompanied by a significant rise in the titer of specific indirect hemagglutinating antibodies [Ab]. Inoculation of M. fermentans into the uterine cavity through the cervical canal without dilatation of the cervix produced practically no signs of inflammation and no Ab response. When the intrauterine inoculation of mycoplasmas was followed by curettage of the endometrium, in animals whose uterine tubes were closed by ligatures, pronounced upper genital-tract inflammation developed, together with a significant Ab response.