Anticonvulsant Action of 2-Substituted-l,3-Propanediols

Abstract

Certain 2-substituted 1,3-propanediols possess a stronger anticonvulsant action and a weaker paralyzing action than myanesin and similar compounds. 2,2-Diethyl-l,3-propanediol (DEP), the outstanding compound of the series, was as active as phenobarbital in preventing the occurrence of convulsions and deaths from lethal doses of metrazol in mice. It was more effective than phenobarbital or myanesin in antagonizing the convulsant and lethal effects of strychnine. DEP was considerably weaker than phenobarbital in preventing the occurrence of electroshock seizures in mice and rabbits.