Age-Related Changes in the Hepatic Endoplasmic Reticulum: A Quantitative Analysis
- 2 September 1977
- journal article
- other
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 197 (4307), 1005-1008
- https://doi.org/10.1126/science.887935
Abstract
Morphometric analysis demonstrated a twofold increase in the surface area of the hepatic endoplasmic reticulum in Fischer 344 rats between 1 and 20 months of age, followed by a significant decrease in this parameter between 20 and 30 months. These changes are attributed to the smooth-surfaced endoplasmic reticulum, since neither the rough-surfaced variety nor the Golgi membranes underwent any significant change in surface area as a function of the age of the animal.Keywords
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