Hemangioblastomas: Clinical and Histopathological Factors Correlated with Recurrence

Abstract

L Hospital between 1974 and 1986, 7 (27%) developed recurrences after surgical extirpation. Recurrence was correlated with younger age, that is <30 years at the time of diagnosis (P < 0.01), von Hippel-Lindau syndrome (P < 0.001), and the presence of multicentric tumors of the central nervous system at initial diagnosis (P < 0.005). Histopathologically, recurring hemangioblastomas had lower frequencies of cyst formation (P = 0.10) and lower proportions of lipid-laden stromal cells (P < 0.05). The findings suggest that a particular constellation of clinical and pathological features can be used to predict the likelihood of recurrence of a hemangioblastoma, and therefore to identify patients in need of long-term follow-up or, possibly, adjunctive therapy. (Neurosurgery 25:695-698, 1989) Copyright © by the Congress of Neurological Surgeons...