Effect of carrier‐specific tolerance on the generation of helper cell function
- 1 October 1976
- journal article
- research article
- Published by Wiley in European Journal of Immunology
- Vol. 6 (10), 742-746
- https://doi.org/10.1002/eji.1830061016
Abstract
The effect of carrier-specific tolerance on the development of helper cell function was studied in irradiated rats reconstituted with normal or carrier-tolerant bone marrow. Bone marrow (BM) from normal rats or rats tolerant to sheep IgG (SGG) was transferred to lethally irradiated syngeneic recipients, which were challenged 3 to 5 weeks later when immunocompetence to T-dependent antigens was shown to have recovered. When recipients were challenged with the 2,4,6-trinitrophenyl (TNP) hapten coupled to SGG in adjuvant, groups which received SGG-tolerant BM were 70–80 % unresponsive in terms of anti-TNP plaque-forming cells compared to recipients of normal BM. This effect was carrier (SGG)-specific and was reversed when normal thymocytes were transferred with tolerant BM. Moreover, neither tolerant BM nor tolerant thymocytes were able to suppress the responsiveness of normal BM at a 1:1 ratio. These cell-mixing experiments imply that the reduction in helper cell function is due neither to suppressor cells nor antigen carryover in the tolerant BM. It is suggested that a BM precursor of the helper T cell may be rendered tolerant and therefore already possesses antigen specificity prior to thymic migration.This publication has 23 references indexed in Scilit:
- Cellular events in tolerance. IV. The effect of a graft‐versus‐host reaction and endotoxin on hapten‐ and carrier‐specific toleranceEuropean Journal of Immunology, 1974
- Allogeneic interactions in the immune response and tolerance: I. The allogeneic effect in unprimed rats and miceCellular Immunology, 1974
- DIFFERENTIATION OF T CELLS INDUCED BY PREPARATIONS FROM THYMUS AND BY NONTHYMIC AGENTSThe Journal of Experimental Medicine, 1973
- Kinetic Differences in Unresponsiveness of Thymus and Bone Marrow CellsScience, 1971
- Role of Thymus-derived Lymphocytes in the Secondary Humoral Immune Response in MiceNature, 1970
- CELLULAR DIFFERENTIATION IN THE THYMUSTransplantation, 1969
- Thymus Dependence of Antibody Response: Variation with Dose of Antigen and Class of AntibodyNature, 1968
- HAPTEN CARRIER RELATIONSHIPS IN THE DNP-PLL·FOREIGN ALBUMIN COMPLEX SYSTEM: INDUCTION OF TOLERANCE AND STIMULATION OF CELLS IN VITROThe Journal of Experimental Medicine, 1968
- THE INFLOW OF BONE MARROW CELLS TO THE THYMUS: STUDIES WITH PART‐BODY IRRADIATED MICE INJECTED WITH CHROMOSOME‐MARKED BONE MARROW AND SUBJECTED TO ANTIGENIC STIMULATIONAnnals of the New York Academy of Sciences, 1966
- ROLE OF THE THYMUS IN TOLERANCEThe Journal of Experimental Medicine, 1965