Chemical Strategies for Activity‐Based Proteomics
- 19 December 2003
- journal article
- review article
- Published by Wiley in ChemBioChem
- Vol. 5 (1), 41-47
- https://doi.org/10.1002/cbic.200300721
Abstract
The assignment of molecular and cellular functions to the numerous protein products encoded by prokaryotic and eukaryotic genomes presents a major challenge for the field of proteomics. To address this problem, chemical approaches have been introduced that utilize small‐molecule probes to profile dynamics in enzyme activity in complex proteomes. These strategies for activity‐based protein profiling enable both the discovery and functional analysis of enzymes associated with human disease.Keywords
This publication has 47 references indexed in Scilit:
- Inhibitors of Endocannabinoid Degradation: Potential Therapeutics for Neurological DisordersAngewandte Chemie International Edition, 2003
- Discovering potent and selective reversible inhibitors of enzymes in complex proteomesNature Biotechnology, 2003
- Activity-Based Protein Profiling in Vivo Using a Copper(I)-Catalyzed Azide-Alkyne [3 + 2] CycloadditionJournal of the American Chemical Society, 2003
- Bioconjugation by Copper(I)-Catalyzed Azide-Alkyne [3 + 2] CycloadditionJournal of the American Chemical Society, 2003
- A Role for the Protease Falcipain 1 in Host Cell Invasion by the Human Malaria ParasiteScience, 2002
- A Stepwise Huisgen Cycloaddition Process: Copper(I)-Catalyzed Regioselective “Ligation” of Azides and Terminal AlkynesAngewandte Chemie International Edition, 2002
- Proteomic profiling of mechanistically distinct enzyme classes using a common chemotypeNature Biotechnology, 2002
- Molecular Complexity and Its Impact on the Probability of Finding Leads for Drug DiscoveryJournal of Chemical Information and Computer Sciences, 2001
- Proteome and proteomics: New technologies, new concepts, and new wordsElectrophoresis, 1998
- In Vivo and in Vitro Binding of Microcystin to Protein Phosphatase 1 and 2ABiochemical and Biophysical Research Communications, 1995