Recovery of immune responsiveness to rabies vaccine after treatment of mice with cyclophosphamide

Abstract

Summary Mice treated with cyclophosphamide (Cy) recovered the ability to mount delayed type hypersensitivity reactions within 3 days. By contrast, antibody production to a T cell independent antigen (E. coli lipopolysaccharide) and to human diploid cell strain rabies vaccine did not occur unless the immunization of Cy-treated mice was delayed for 7–10 days. No significant resistance to rabies infection was recorded at 10 days but was demonstrable if 14 days had elapsed between Cy treatment and vaccination.