Effect of Aureomycin on Hepatic Utilization of Labeled Body Fat in Rats.

Abstract

Oral administration of 5 mg chlortetracycline (Aureomycin) to rats, the body fat of which had been labeled previously with Cl4-tripalmitin, did not result in accumulation of excessive C14 activity in hepatic fatty acids. The amount and radioactivity of total fatty acids of carcass and of intestine were likewise similar in experimental and control animals. A 4-day metabolic balance study showed that from 81 to 93% of the fed tripalmitin was absorbed.