Evidence for an involvement of the brain cholecystokinin B receptor in anxiety.
- 15 February 1991
- journal article
- research article
- Published by Proceedings of the National Academy of Sciences in Proceedings of the National Academy of Sciences
- Vol. 88 (4), 1130-1133
- https://doi.org/10.1073/pnas.88.4.1130
Abstract
The effect of neuropeptide cholecystokinin (CCK) receptor agonists and antagonists was examined in the rat elevated X-maze model of anxiety. The selective CCK-B receptor antagonists CI-988 (PD 134308) and L-365,260 produced anxiolytic-like effects, whereas MK-329, a CCK-A receptor antagonist, was respectively less potent by factors of 313 and 200. The intracerebroventricular administration of the nonselective CCK receptor agonist caerulein or the selective CCK-B receptor agonist pentagastrin increased dose dependently the level of anxiety. CI-988 dose dependently antagonized the anxiogenic response to pentagastrin but not that induced by pentylenetetrazol. These results strongly suggest that activation of the brain CCK-B receptor induces anxiety and that selective antagonists of this receptor represent a separate class of anxiolytic agents.Keywords
This publication has 21 references indexed in Scilit:
- Postponement of Satiety by Blockade of Brain Cholecystokinin (CCK-B) ReceptorsScience, 1989
- CCK8 effects on motivational and emotional states of rats involve CCKA receptors of the postero-median part of the nucleus accumbensPharmacology Biochemistry and Behavior, 1989
- A new potent and selective non-peptide gastrin antagonist and brain cholecystokinin receptor (CCK-B) ligand: L-365,260European Journal of Pharmacology, 1989
- Species differences in the localization of ‘peripheral’ type cholecystokinin receptors in rodent brainNeuroscience Letters, 1987
- Validation of open : closed arm entries in an elevated plus-maze as a measure of anxiety in the ratJournal of Neuroscience Methods, 1985
- Molecular Forms of Cholecystokinin in the Brain and the Relationship to Neuronal GastrinsaAnnals of the New York Academy of Sciences, 1985
- The morphology and distribution of peptide-containing neurons in the adult and developing visual cortex of the rat. III. CholecystokininJournal of Neurocytology, 1982
- Degradation of cholecystokinin-like peptides by a crude rat brain synaptosomal fraction: A study by high pressure liquid chromatographyRegulatory Peptides, 1981
- Immunochemical evidence of cholecystokinin-like peptides in brainNature, 1976
- METRAZOL TOLERANCE IN A “NORMAL” VOLUNTEER POPULATIONJournal of Nervous & Mental Disease, 1970