Effects of metabolic inhibitors on the rat uterus and on its response to oxytocin
- 1 February 1964
- journal article
- research article
- Published by American Physiological Society in American Journal of Physiology-Legacy Content
- Vol. 206 (2), 437-442
- https://doi.org/10.1152/ajplegacy.1964.206.2.437
Abstract
Myometrial strips from white rats between the 6th and 9th and the 20th and 22nd days of pregnancy were arranged for the simultaneous recording of membrane potentials from single muscle fibers and isometric tension from the entire strip. The 6- to 9-day uteri behaved as though they were progesterone controlled, while the 20- to 22-day muscles seemed to be under the control of estrogen. Dinitrophenol (DNP) (10–3 m) depolarized the muscle cell membrane and stopped all contractions in the 6- to 9-day uteri, but only diminished the contractions in the 30- to 22-day muscles. In both groups of muscles, DNP (10–3 m) abolished the stimulatory action of oxytocin. The inhibitory action of DNP was reversible. Monoiodoacetic acid (IAA) (2 x 10–4 m) abolished all activity and the response to oxytocin in both groups of muscles but, in contrast to DNP, there was no change in the level of the resting membrane potential. The action of IAA was irreversible.Keywords
This publication has 18 references indexed in Scilit:
- The effect of metabolic inhibitors on the sodium fluxes in sodium‐loaded frog sartorius muscleThe Journal of Physiology, 1959
- ELECTROCHEMICAL ASPECTS OF PHYSIOLOGICAL AND PHARMACOLOGICAL ACTION IN EXCITABLE CELLS .1. THE RESTING CELL AND ITS ALTERATION BY EXTRINSIC FACTORS1958
- ESTROGEN-SENSITIVE ISOCITRIC DEHYDROGENASEJournal of Biological Chemistry, 1957
- THE OXIDATION OF REDUCED TRIPHOSPHOPYRIDINE NUCLEOTIDE AS MEDIATED BY THE TRANSHYDROGENASE REACTION AND ITS INHIBITION BY THYROXINEProceedings of the National Academy of Sciences, 1957
- The effect of metabolic inhibitors on the electrical and mechanical activity of the smooth muscle of the guinea-pig's taenia coliThe Journal of Physiology, 1957
- THE EFFECT OF THYROXINE AND RELATED COMPOUNDS ON OXIDATIVE PHOSPHORYLATIONJournal of Biological Chemistry, 1956
- The effect of steroids on the maintenance of pregnancy in the spayed rat*The Journal of Physiology, 1955
- Active transport of cations in giant axons from Sepia and LoligoThe Journal of Physiology, 1955
- The effect of 2:4‐dinitrophenol (DNP) on the smooth muscle of the guinea‐pig's taenia coliThe Journal of Physiology, 1955
- REVERSIBLE INHIBITION OF THE COUPLING BETWEEN PHOSPHORYLATION AND OXIDATIONJournal of Biological Chemistry, 1948