Harnessing transposons for cancer gene discovery
- 16 September 2010
- journal article
- review article
- Published by Springer Nature in Nature Reviews Cancer
- Vol. 10 (10), 696-706
- https://doi.org/10.1038/nrc2916
Abstract
Recently, it has become possible to mobilize the Tc1/mariner transposon, Sleeping Beauty (SB), in mouse somatic cells at frequencies high enough to induce cancer. Tumours result from SB insertional mutagenesis of cancer genes, thus facilitating the identification of the genes and signalling pathways that drive tumour formation. A conditional SB transposition system has also been developed that makes it possible to limit where SB mutagenesis occurs, providing a means to selectively model many types of human cancer. SB mutagenesis has already identified a large collection of known cancer genes in addition to a plethora of new candidate cancer genes and potential drug targets.Keywords
This publication has 107 references indexed in Scilit:
- Comparative Analysis of Transposable Element Vector Systems in Human CellsMolecular Therapy, 2010
- 53BP1 loss rescues BRCA1 deficiency and is associated with triple-negative and BRCA-mutated breast cancersNature Structural & Molecular Biology, 2010
- Response and resistance to MEK inhibition in leukaemias initiated by hyperactive RasNature, 2009
- A conditional transposon-based insertional mutagenesis screen for genes associated with mouse hepatocellular carcinomaNature Biotechnology, 2009
- Pivotal Role of mTOR Signaling in Hepatocellular CarcinomaGastroenterology, 2008
- Large-Scale Mutagenesis in p19ARF- and p53-Deficient Mice Identifies Cancer Genes and Their Collaborative NetworksCell, 2008
- piggyBac can bypass DNA synthesis during cut and paste transpositionThe EMBO Journal, 2008
- Sleeping Beauty transposase modulates cell-cycle progression through interaction with Miz-1Proceedings of the National Academy of Sciences, 2006
- Mutations of the BRAF gene in human cancerNature, 2002
- The Hallmarks of CancerCell, 2000