Total Synthesis of (−)-Callystatin A
- 18 December 2001
- journal article
- Published by American Chemical Society (ACS) in The Journal of Organic Chemistry
- Vol. 67 (9), 2751-2754
- https://doi.org/10.1021/jo016025d
Abstract
A total synthesis of the cytotoxic polyketide marine natural product callystatin A is described. The route features chiral allenylmetal additions to construct the polypropionate C15−22 segment and an sp2−sp3 Suzuki coupling to join the C1−C11 and C12−C22 subunits.Keywords
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