Bruton Tyrosine Kinase (BTK) and Its Role in B-cell Malignancy
Top Cited Papers
- 21 March 2012
- journal article
- review article
- Published by Taylor & Francis in International Reviews of Immunology
- Vol. 31 (2), 119-132
- https://doi.org/10.3109/08830185.2012.664797
Abstract
BTK is a kinase that functions downstream of multiple receptors in various hematologic cells. This review focuses on BTK-dependent pathways that are likely to be involved in maintaining the malignant phenotype in B-cell lymphomas and leukemias. Survival of various B-cell malignancies requires BTK-dependent signals from the B-cell antigen receptor. Survival is also dependent on malignant cells homing to and interacting with lymphoid microenvironments, and these interactions are also BTK-dependent due its role in signaling downstream of chemokine and innate immune receptors. The potential for therapeutic targeting of BTK is currently being tested in clinical settings.Keywords
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