Histocompatibility and Isoenzyme Differences in Commercially Supplied BALB/c Mice: A Reply

Abstract

With the recent increased demand for both inbred and hybrid mice and rats, a common potential variable is the lack of genetic integrity in animal models used, regardless of whether they were acquired from commercial sources or from the investigtors'' own breeding colony. A mutual responsibility must be exercised by both the supplier of laboratory animals and the user of animals to promptly report to each other any discrepancy in results which may provide an early warning that a potential problem might exist.