Cytomegalic-Inclusion Disease in the Adult

Abstract

THE occurrence of cytomegaly with intranuclear inclusions is well recognized in newborn and older infants. This cellular alteration may be incidentally encountered at autopsy in salivary glands or less frequently disseminated in other viscera. On occasion it has been considered pathognomonic of a disease in infants characterized by jaundice, hemolytic anemia, thrombocytopenia, purpura, pneumonitis and cerebral calcification. Diagnosis during life may be facilitated by observation of the characteristic cells in the urinary sediment¹ or gastric washings² or in biopsies from the lung³ or liver.⁴ In patients with this disease the isolation of a virus producing identical cytologic changes in tissue . . .