Aldosterone effects on renal metabolism.

Abstract

Manometric studies of the Na dependent O2 consumption in rat kidney slices failed to reveal any significant effect of aldosterone treatment, adrenalectomy or Na diet on Na metabolism. Ammonia release from kidney slices was significantly reduced following adrenalectomy and this decrease was influenced by aldosterone treatment. The dose-response characteristic obtained for this aldosterone-stimulated ammonia release was determined. The effect of a high Na+ diet on the ammonia release was studied. An initial decrease after 2 days may be associated with decreased endogenous aldosterone secretion. Aldosterone (2.5 .mu.g/100 g body wt) injections into these high Na+ treated animals fails to restore the normal ammonia release. The effects of aldosterone (2.5 .mu.g/100 g body wt), dexamethasone (2.5 .mu.g/100 g body wt) and corticosterone (2.5 .mu.g/100 g body wt) injections, in adrenalectomized rats, on ammonia release and tissue tyrosine aminotransferase activities were compared.