Production of Macroglobulins in Vitro and a Study of Their Cellular Origin
Open Access
- 1 July 1962
- journal article
- research article
- Published by American Society of Hematology in Blood
- Vol. 20 (1), 56-64
- https://doi.org/10.1182/blood.v20.1.56.56
Abstract
Lymph nodes of three patients with macroglobulinemia of Waldenström were studied in tissue culture and shown to synthesize 19S γ-globulin in vitro. Lymph node imprints, bone marrow, and buffy coat smears of the same patients consisted almost entirely of lymphocytes. When these were stained with fluorescein-conjugated antiserum to macroglobulin, large and medium-sized lymphocytes and lymphoblasts rather than mature lymphocytes or plasma cells were shown to contain the protein. It is suggested that 19S γ-globulin may also be synthesized by cells belonging to the lymphoid series under normal circumstances.This publication has 9 references indexed in Scilit:
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