CHARACTERIZATION OF INTRA‐TUMORAL PORPHYRIN FOLLOWING INJECTION OF HEMATOPORPHYRIN DERIVATIVE OR ITS PURIFIED COMPONENT*
- 1 July 1987
- journal article
- research article
- Published by Wiley in Photochemistry and Photobiology
- Vol. 46 (1), 67-70
- https://doi.org/10.1111/j.1751-1097.1987.tb04737.x
Abstract
Photodynamic therapy (PDT) utilizes either hematoporphyrin derivative (Hpd) or a purified form of Hpd termed DHE, as photosensitizers for treatment of a variety of solid tumors in man. The reasons for long retention of these porphyrins in a wide range of histologically diverse tumors remain obscure. We have found that the RIF fibrosarcoma and SMT-F mammary carcinoma in mice, a intrapancreatic tumor in the hamster and a tumor removed from a patient with a myxoid sarcoma, may take up Hpd or DHE by endocytosis. On the other hand, the RIF tumor cells in vitro show a tendency for selective uptake and retention of the more hydrophobic components of the mixture.This publication has 8 references indexed in Scilit:
- TUMOR DESTRUCTION AND KINETICS OF TUMOR-CELL DEATH IN 2 EXPERIMENTAL MOUSE-TUMORS FOLLOWING PHOTODYNAMIC THERAPY1985
- Photodynamic therapy (PDT) of malignant tumorsCritical Reviews in Oncology/Hematology, 1984
- Uptake of the components of hematoporphyrin derivative by cells and tumoursCancer Letters, 1983
- Current knowledge of pancreatic carcinogenesis in the hamster and its relevance to the human diseaseCancer, 1981
- AUTORADIOGRAPHIC DISTRIBUTION OF HEMATOPORPHYRIN DERIVATIVE IN NORMAL AND TUMOR-TISSUE OF THE MOUSE1981
- A New Mouse Tumor Model System (RIF-1) for Comparison of End-Point Studies23JNCI Journal of the National Cancer Institute, 1980
- DETERMINATION OF [HEMATOPORPHYRIN-H-3] AND [HEMATOPORPHYRIN-C-14 DERIVATIVE DISTRIBUTION IN MALIGNANT AND NORMAL TISSUE1979
- A Membrane Effect of Basic Polymers dependent on Molecular SizeNature, 1967