Effect of Bovine Gamma Globulin on Subsequent Immunization with Dinitrophenylated Bovine Gamma Globulin.

Abstract

Summary Rabbits were immunized with bovine gamma globulin intravenously in saline and were reinjected with dinitrophenylated bovine gamma globulin intravenously. No secondary effect on anti-dinitrophenyl antibodies was observed by prior injection of bovine gamma globulin; on the contrary, no anti-dinitrophenyl antibody was produced in these animals whereas in controls, which had not received prior bovine gamma globulin injections, antibody production was detected, especially with highly derivated dinitrophenyl-bovine gamma globulin preparations. A secondary effect against bovine gamma globulin was observed, especially with the less derivated preparation.