A retrospective study of serial CEA determinations in the early detection of recurrent colorectal cancer
- 1 November 1981
- journal article
- research article
- Published by Wolters Kluwer Health in Diseases of the Colon & Rectum
- Vol. 24 (8), 618-621
- https://doi.org/10.1007/bf02605759
Abstract
In the past 5 yr, routine CEA (carcinoembryonic antigen) determinations were carried out on all patients after curative operation for colorectal carcinoma. These patients also underwent a clinical follow-up examination. In 86 patients, recurrence of a tumor was confirmed. In 31 cases, a 2nd-loop operation was carried out. The CEA determinations were retrospectively analyzed in these patients and correlated with the time the recurrence of the tumor was diagnosed. These results show that of 86 patients only 15 (17.4%) had pathologic CEA values before clinical symptoms of tumor recurrence. In the patient group with local recurrence, only 11 (23.9%) of 46 patients had previously pathologically raised CEA values. Of 31 patients, 15 (48.4%) underwent curative resection after the 2nd-look operation. At this time, 12 patients (38.7%) still had normal CEA values, whereas only 3 patients (9.7%) had pathologically raised CEA values. Early diagnosis of tumor recurrence was very low, therefore one should not rely more on postoperative routine CEA determinations in the postoperative monitoring of patients following curative operations for colorectal carcinoma than on regular comprehensive follow-up examinations of these patients.Keywords
This publication has 13 references indexed in Scilit:
- Results of CEA-initiated second-look surgery for recurrent colorectal cancerThe American Journal of Surgery, 1980
- A retrospective and prospective study of serial CEA determinations in the early detection of recurrent colon cancerThe American Journal of Surgery, 1979
- Slope analysis of the postoperative CEA time course and its possible application as an aid in diagnosis of disease progression in gastrointestinal cancerThe American Journal of Surgery, 1978
- The use of serial CEA determinations to predict recurrence of colon cancer and when to do a second-look operationCancer, 1978
- Carcinoembryonic Antigen Test for Recurrent Colorectal CarcinomaPublished by American Medical Association (AMA) ,1978
- The USE of CEA as an early indicator for gastrointestinal tumor recurrence and second-look proceduresCancer, 1977
- Abdominoperineal resection following anterior resectionCancer, 1976
- Carcinoma of the rectum: Treatment by anterior resection or abdominoperineal excision?Diseases of the Colon & Rectum, 1973
- Anterior resection versus abdominoperineal resection for cancer of the rectum and rectosigmoid: An analysis of 524 casesThe American Journal of Surgery, 1972
- Pelvic Recurrence after Excision of Rectum for CarcinomaBMJ, 1963