Augmentation of Vasoactive Substances by Tetraethylammonium Chloride
- 1 June 1950
- journal article
- research article
- Published by Wolters Kluwer Health in Circulation
- Vol. 1 (6), 1233-1245
- https://doi.org/10.1161/01.cir.1.6.1233
Abstract
This investigation attempts to demonstrate the mechanism by which substances that block autonomic ganglionic transmission increase the pressor and depressor activities of a variety of drugs. Short-lived hypertension and a high degree of vascular responsiveness is induced by combining cord destruction, inactivation of the carotid sinus mechanism and nephreetomy. The increased responsiveness is found to be due to removal of the compensatory nervous mechanisms which tend to oppose changes in blood pressure. It may be reduced or abolished by hepatectomy, severe hypotension and shock.Keywords
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