Pharmacokinetic Interactions of Nevirapine and Methadone and Guidelines for Use of Nevirapine to Treat Injection Drug Users
Open Access
- 1 November 2001
- journal article
- Published by Oxford University Press (OUP) in Clinical Infectious Diseases
- Vol. 33 (9), 1595-1597
- https://doi.org/10.1086/322519
Abstract
Administration of nevirapine to HIV-infected injection drug users who also receive methadone results in a significant reduction in methadone exposure after 7–10 days of therapy. Many patients require an increase in methadone dose to counteract this effect.Keywords
This publication has 11 references indexed in Scilit:
- The pharmacokinetics of methadone in HIV‐positive patients receiving the non‐nucleoside reverse transcriptase inhibitor efavirenzBritish Journal of Clinical Pharmacology, 2001
- The steady-state pharmacokinetics of nevirapine during once daily and twice daily dosing in HIV-1-infected individualsAIDS, 2000
- Nevirapine induced opiate withdrawal among injection drug users with HIV infection receiving methadoneAIDS, 1999
- Nevirapine-induced withdrawal symptoms in HIV patients on methadone maintenance programme: an alertAIDS, 1999
- Methadone Withdrawal when Starting an Antiretroviral Regimen Including NevirapinePharmacotherapy: The Journal of Human Pharmacology and Drug Therapy, 1999
- The effect of fluconazole on the clinical pharmacokinetics of methadone*Clinical Pharmacology & Therapeutics, 1998
- Involvement of Cytochrome P450 3A4 Enzyme in the N-Demethylation of Methadone in Human Liver MicrosomesChemical Research in Toxicology, 1996
- Enzyme induction and inhibitionPharmacology & Therapeutics, 1990
- Phenytoin-Induced Methadone WithdrawalAnnals of Internal Medicine, 1981
- Rifampin-Induced Methadone WithdrawalNew England Journal of Medicine, 1976