Plasma Immunoreactive Insulin after Intestinal Administration of –βNaphthyl—Azo—Polystyrene—Insulin to the Rabbit

Abstract

Insulin was bound physically to diazopolystyrene quenched with β—naphthol. When β—naphthyl—azo—polystyrene—insulin thus prepared was administered to the jejunum of rabbits, there was a significant increase in plasma insulin concentrations, followed by a significant fall in blood glucose. The plasma insulin concentrations following administration of β—naphthyl—azo—polystyrene— insulin were 2–3 times higher than those following infusion of crystalline insulin. These results indicate a possible means of protecting insulin molecule from digestive destruction. (Endocrinology91: 320, 1972)