— Scanning Electron Microscopic Observation of Amyloid‐Laden Mouse Liver —

Abstract

Amyloidosis of liver in mice induced by casein injection was studied by scanning electron microscopy (SEM). In the fractured-surfaces of the central portion of amyloid nodules, they appeared as chestnut-bur-like structures and were composed of numerous thread-like structures of fasciculated amyloid fibrils and of stick-like structures of amyloid bundles in 3 dimensional figures. In the cytoplasm of the Kupffer cell, amyloid bundles were revealed as band-like bulges. These bulges were projected from the Kupffer cell into the Disse''s space and continued with thread-like structures outside the cytoplasm of Kupffer cells.