Use of New Chiral Hydrophilic Gels dor the Direct Resolution α-Aminoacids by High Pressure Liquid Chromatography

Abstract
Total resolution of α-aminoacids was achieved by H P L C using porous gels based on acrylamide grafted with chiral substituents (L-α aminoacids) and complexed with metal ions. We discuss the influence of the structure of the gel (porosity, hydrophilicity and coordination affinity), of the kinetics of the ligand exchange, of the nature of the complexing ion and of the chiral graft.