Cocaine Radioimmunoassay-Structure Versus Reactivity
- 1 January 1981
- journal article
- research article
- Published by Taylor & Francis in Clinical Toxicology
- Vol. 18 (7), 773-782
- https://doi.org/10.3109/15563658108990304
Abstract
Twenty-seven different cocaine-related substances were analyzed by radioimmunoassay (RIA) at several concentrations. An attempt was made to relate structural differences to the affinity of the compounds with the RIA benzoylecgonine (cocaine metabolite) antibody. The effects of substituent placement in the cocaine molecule were studied. Adding an alkyl group to the 2-carboxylic acid (conversion to an alkyl ester) increased reactivity, whereas changes in all other positions reduced reactivity.This publication has 3 references indexed in Scilit:
- Evaluation of the radioimmunoassay for benzoylecgonine (a cocaine metabolite) in human urine.Clinical Chemistry, 1977
- Thin-layer chromatographic analysis of cocaine and benzoylecgonine in urineJournal of Chromatography A, 1975