Myelin Gangliosides in Vertebrates
- 1 September 1982
- journal article
- research article
- Published by Wiley in Journal of Neurochemistry
- Vol. 39 (3), 773-779
- https://doi.org/10.1111/j.1471-4159.1982.tb07959.x
Abstract
A phylogenetic survey of brain myelin ganglioside patterns and concentrations has been carried out on 16 vertebrate species. Gangliosides were isolated from purified myelin and found to vary in concentration from 25 μg of sialic acid per 100 mg of myeh for goldfish to a value of 395 for turkey. The latter species had approximately equivalent amounts of GM1 and GM4 as the two major gangliosides. The 11 mammals studied all had GM1 as the major ganglioside, with variable amounts of GM4; rhesus monkey and human had 20-25% GM4, whereas the others had less than 10%. Amphibia and fish myelin contained the least total ganglioside, with patterns that showed relatively little GM1 and no detectable GM4. Alligator myelin was unique in having a total concentration as high as the avian species, but a pattern with predominantly diand trisialo gangliosides.Keywords
This publication has 33 references indexed in Scilit:
- Gangliosides associated with microsomal subfractions of brain: Comparison with synaptic plasma membranesJournal of Neurobiology, 1982
- The Lipid Composition of Rat CNS Axolemma‐enriched FractionsJournal of Neurochemistry, 1980
- Dissociation of axonally transported proteins from myelin by ethylenediamine tetraacetate (EDTA)Journal of Neurochemistry, 1978
- GANGLIOSIDES OF PERIPHERAL NERVE MYELINJournal of Neurochemistry, 1976
- BRAIN GANGLIOSIDE PATTERNS OF VERTEBRATESJournal of Neurochemistry, 1971
- Characterization of gangliosides from fish brainBiochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism, 1970
- Further evidence for a specific ganglioside fraction closely associated with myelinBiochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism, 1968
- Gangliosides in the myelin fraction of developing ratsBiochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism, 1967
- CHEMICAL COMPOSITION OF MYELIN AND OTHER SUBCELLULAR FRACTIONS ISOLATED FROM BOVINE WHITE MATTER*Journal of Neurochemistry, 1966
- Quantitive estimation of sialic acidsBiochimica et Biophysica Acta, 1957