Suppression of Established Friend Virus Leukemia by Statolon VII. Relative Roles of Interferon and the Immune Response in Development of FV-Dormant Infections

Abstract

Interferon induction and transient clearance of FV from the blood of leukemic mice are not sufficient by themselves to induce remissions. Of the interferon inducers tested, only statolon abrogates immunodepression, stimulates FV-cytotoxic antibody, and converts a rapidly lethal FV infection to a dormant state resulting in prolonged clinical remissions.