A STUDY OF POTENTIAL HISTIDINE DECARBOXYLASE INHIBITORS
Open Access
- 1 December 1960
- journal article
- research article
- Published by Wiley in British Journal of Pharmacology and Chemotherapy
- Vol. 15 (4), 552-556
- https://doi.org/10.1111/j.1476-5381.1960.tb00279.x
Abstract
A series of compounds has been examined for ability to inhibit histidine decarboxylase. Histidine analogues having substituents in the imidazole ring showed a wide variation in potency, but these were all much less active than α-methyldopa [β-(3,4-dihydroxyphenyl)-α-methylalanine], the most potent known inhibitor of histidine decarboxylase. Some tentative conclusions are drawn regarding the relationship between chemical structure and inhibitory activity.Keywords
This publication has 11 references indexed in Scilit:
- THE PHARMACOLOGICAL ACTIONS OF 3,4‐DIHYDROXY‐PHENYL‐α‐METHYLALANINE (α‐METHYLDOPA), AN INHIBITOR OF 5‐HYDROXYTRYPTOPHAN DECARBOXYLASEBritish Journal of Pharmacology and Chemotherapy, 1960
- A PLACE FOR HISTAMINE IN NORMAL PHYSIOLOGYThe Lancet, 1960
- STUDIES ON MAMMALIAN HISTIDINE DECARBOXYLASEBritish Journal of Pharmacology and Chemotherapy, 1956
- Inhibition of dihydroxyphenylalanine decarboxylase by derivatives of phenylalanineArchives of Biochemistry and Biophysics, 1954
- A General Mechanism for Vitamin B6-catalyzed Reactions1Journal of the American Chemical Society, 1954
- Studies on Imidazoles. III. 1-Substituted Analogs of Histidine and HistamineJournal of the American Chemical Society, 1949
- Preparation and Properties of the Iodohistidines1Journal of the American Chemical Society, 1947
- The Determination of Enzyme Dissociation ConstantsJournal of the American Chemical Society, 1934
- Reaktionen zwischen Zuckerarten und deren Abbauprodukten mit stickstoffhaltigen Substanzen. 1. Mitteilung. Zur Bildung von Imidazolen.Hoppe-Seyler´s Zeitschrift Für Physiologische Chemie, 1929
- CCXXXII.—Some derivatives of 4(or 5)-methylglyoxalineJournal of the Chemical Society, Transactions, 1911