Palladium-catalysed asymmetric allylic alkylation in the presence of a chiral ‘light fluorous’ phosphine ligand

Abstract

The easily accessible, enantiopure (R)-(+)-2-diarylphosphino-2′-alkoxy-1,1′-binaphthyl 1 bearing three fluorous ponytails is an efficient ligand in the palladium-catalysed asymmetric allylic substitution of 1,3-diphenylprop-2-enyl acetate affording chiral products of up to 87% ee.