Influence on Blood Pressure of Renal Isografts between Spontaneously Hypertensive and Normotensive Rats, Utilizing the F1 Hybrids

Abstract

The F1 hybrids (F1) of spontaneously hypertensive rats (SHR) and Wistar rats (W), whose kidneys were transplanted from SHR at the age of 10 wk and 20 wk, showed significant elevation of blood pressure (BP) for 11 wk after transplantation. In F1 with W or F1 kidneys, BP decreased near to normal level. F1 whose kidneys were transplanted from SHR or W showed low plasma and renal renin activity. BP of SHR Is probably determined by the renal hypertensive factor(s) other than renin influencing on sympathetic nerves through CNS.